Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure
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چکیده
منابع مشابه
Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure.
Widespread changes in cardiac gene expression occur during heart failure, yet the mechanisms responsible for coordinating these changes remain poorly understood. The Mediator complex represents a nodal point for modulating transcription by bridging chromatin-bound transcription factors with RNA polymerase II activity; it is reversibly regulated by its cyclin-dependent kinase 8 (Cdk8) kinase sub...
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Heart failure presents a number of difficulties. Its very definition has proved taxing, and the clinical diagnosis is frequently incorrect. Patients with objective abnormalities of left ventricular function are not infrequently asymptomatic, hence treatment is often delayed. Even when a firm diagnosis is secured, only a minority of patients receive optimal medical treatment. Of concern is the i...
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1. Introduction Administration Heart Failure Trial) and other trials suggest that death is disproportionately sudden in patients with Over 2 million Americans suffer from heart failure and more modest myocardial dysfunction [8]. A major caveat more than 200 000 die annually. The incidence is esti-is that the mechanism of sudden death is highly heteroge-mated to be 400 000 per year with a preval...
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Pathological cardiac hypertrophy inevitably leads to the unfavorable outcomes of heart failure (HF) or even sudden death. microRNAs are key regulation factors participating in many pathophysiological processes. Recently, we observed upregulation of microRNA-340-5p (miR-340) in failing human hearts because of dilated cardiomyopathy, but the functional consequence of miR-340 remains to be clarifi...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2017
ISSN: 2379-3708
DOI: 10.1172/jci.insight.92476